Product Description: AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
Applications: Neuroscience-Neuromodulation
Formula: C27H38N6O2
References: [1]Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33./[2]Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46.
CAS Number: 118290-26-9
Molecular Weight: 478.63
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: mAChR
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