Product Description: Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C55H96N14O13
Citations: Brain Res. 2023 Oct 5:1821:148619./Oral Dis. 2023 Oct 9./Cell Stress Chaperones. 2024 Apr 21:S1355-8145(24)00067-1./Research Square Print. 2022 Aug.
References: [1]Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73./[2]Wang N, et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309.
CAS Number: 1507930-57-5
Molecular Weight: 1161.44
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Gap Junction Protein
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