Product Description: SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
Applications: COVID-19-immunoregulation
Formula: C23H31Cl2N7O
References: [1]Jenh CH, et al. A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 2012 Jan 10;13:2./[2]Zhang X, et al. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol. 2016 Jan;64(1):160-70./[3]Yue C, et al. STAT3 in CD8<sup>+</sup> T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis. Cancer Immunol Res. 2015 Aug;3(8):864-870.
CAS Number: 906805-42-3
Molecular Weight: 492.44
Compound Purity: 98.71
Research Area: Inflammation/Immunology; Endocrinology
Solubility: DMSO : 2.5 mg/mL (ultrasonic)
Target: CXCR
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