TRK-IN-23, CAS 2924344-29-4

Product Description: TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].

Applications: Cancer-Kinase/protease

Formula: C20H17FN4O2

References: [1]Qiaohua Qin, et al. Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors. Eur J Med Chem. 2023 May 5;253:115291.

CAS Number: 2924344-29-4

Molecular Weight: 364.37

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Trk Receptor

• Artikelnummer: MEXHY-149965-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-149965-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK