VVD-699, CAS 3055319-82-6

Product Description: VVD-699 is a covalent RAS-PI3K inhibitor. VVD-699 covalently binds to cysteine 242 in the RAS binding domain of PI3K p110α, thereby blocking the ability of RAS to activate PI3K activity. VVD-699 is able to inhibit the growth of RAS-mutated and HER2-overexpressing tumors. VVD-699 can be used to study cancers associated with RAS mutations (e.g., H358 lung cancer cells, A549 cells, FaDu cells)[1].

Applications: Cancer-Kinase/protease

Formula: C25H30ClFN2O6S2

References: [1]Klebba JE,et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001. PMCID: PMC11703231.1.

CAS Number: 3055319-82-6

Molecular Weight: 573.10

Research Area: Cancer

Target: PI3K;Ras

• Artikelnummer: MEXHY-173405-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-173405-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK