Product Description: Lipopolysaccharides, from E. coli O127:B8 is a lipopolysaccharide endotoxin from E. coli O127:B8 and TLR-4 activator, Activates disease-associated molecular patterns (PAMPs) of the immune system and induces cell secretion of migratory bodies. Lipopolysaccharides, from E. coli O127:B8 consists of an antigen-specific O-chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O127:B8 can induce changes in body temperature in rats and is dose and serotype specific. High dose of Lipopolysaccharides, from E. coli O127:B8 can cause a double change of body temperature in rats, that is, hypothermia followed by fever. In addition, Lipopolysaccharides, from E. coli O127:B8 can induce inflammation and inhibit reproduction, and can significantly increase the mitotic activity of mollusks[1][2][3][4][5][6][7].
Formula: N/A
References: [1]Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404./[2]Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337./[3]Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32./[4]Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433./[5]Dogan M D,et al. Effects of different serotypes of Escherichia coli lipopolysaccharides on body temperature in rats[J]. Life sciences, 2000, 67(19): 2319-2329./[6]Castellini C,et al. Effect of LPS-induced inflammatory state on some aspects of reproductive function of rabbit does [lipopolysaccharides][J]. Italian Journal of Animal Science (Italy), 2005, 4(2)./[7]Sullivan J T,et al. Effect of crude lipopolysaccharide from Escherichia coli O127: B8 on the amebocyte-producing organ of Biomphalaria glabrata (Mollusca)[J]. Developmental & Comparative Immunology, 2011, 35(11): 1182-1185.
Molecular Weight: N/A
Research Area: Inflammation/Immunology
Solubility: H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Toll-like Receptor (TLR)
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