Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[(3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]butoxy]-benzeneacetic acid
Purity: ≥98%
Formula Markup: C34H33ClF3NO3
Formula Weight: 596.078669
CAS Number: 610318-54-2
Notes: An LXRa and LXRß agonist; induces recruitment of an SRC-1 fragment in cell-free FRET-based assays (EC50s = 74 and 25 nM for LXRa and LXRß, respectively); induces cholesterol efflux in RAW 264.7 macrophages (EC50 = 17 nM); increases plasma levels of VLDL, LDL, and triglycerides in hamsters at 10 mg/kg twice per day and decreases plasma levels of HDL in the same animals at 30 mg/kg twice per day; increases hepatic levels of triglycerides in hamsters at 10 or 30 mg/kg per day; increases serum levels of ApoB in cynomolgus monkeys at 10 mg/kg per day; decreases PHMG-induced increases in lung tissue levels of fibronectin and collagen 1A1 and BALF levels of foam macrophages in a mouse model of pulmonary fibrosis at 20 mg/kg per day
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