Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (E)-N-methyl-4-(pyridin-3-yl)but-3-en-1- amine, hydrochloride
Purity: ≥98%
Formula Markup: C10H14N2 / XHCl
Formula Weight: 162.23164
Notes: An a4ß2 subunit-containing nAChR agonist; selectively induces rubidium ion efflux in M10 cells expressing a4ß2 subunit-containing nAChRs (EC50 = 0.73 µM for the chicken channels) over M10 cells expressing a3ß4- or a1ß1?d subunit-containing receptors (EC50s = >1,000 nM for both for the chicken channels) and a panel of 34 receptors, ion channels, and kinases at 10 µM; induces contractions in isolated guinea pig ileum (EC30 = 15 µM); prevents scopolamine-induced memory deficits in the passive avoidance test in mice at 0.6 µmol/kg; decreases the number of errors in the radial arm maze in a rat model of ibotenic acid-induced memory impairment at 0.3, 0.6 or 1.2 µmol/kg
Deutsch
English
