Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]-benzeneacetic acid
Purity: ≥98%
Formula Markup: C16H13F4NO2
Formula Weight: 327.273572
CAS Number: 220991-32-2
Notes: An NSAID and COX-2 inhibitor (Ki = 30 nM for the human enzyme); selective for COX-2 over COX-1 (Ki = 800 nM for the ovine enzyme); inhibits IL-1β-induced PGE2 production in human dermal fibroblasts (IC50 = 31 nM); reduces carrageenan-induced paw edema (ID50 = 0.4 mg/kg), has antinociceptive activity in the Randall-Selitto test, and inhibits LPS-induced fever in rats