Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanine
Amino Acids: RPKPQQF-OH
Purity: ≥98%
Formula Markup: C41H65N13O10 / XCF3COOH
Formula Weight: 900.0
Notes: A peptide fragment of substance P; induces internalization of the NK1 receptor in isolated rat striatal slices at 10 nM; inhibits substance P-induced contralateral rotation in rats and substance P-induced substantia nigra dopamine release in anesthetized rats; decreases mean arterial pressure and heart rate in anesthetized rats; reduces withdrawal jumping in morphine-dependent mice when administered intrathecally at 1 nmol/animal; increases the latency to tail-flick in the tail-flick test in streptozotocin-induced diabetic mice, an effect that can be reversed by naloxone or (+)-pentazocine but not naltrindole, β-funaltrexamine, norbinaltorphimine, or BD 1047; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity, at 35 pmol/animal
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