Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-cyclopropyl-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-benzeneacetamide
Purity: ≥98%
Formula Markup: C20H21F3N2O2
Formula Weight: 378.4
CAS Number: 953778-63-7
Notes: A T-type calcium channel inhibitor (IC50s = 89, 92, and 98 nM for Cav3.1, Cav3.2, and Cav3.3, respectively, in patch-clamp assays at -80 mV); selective for these channels over Cav1.2, Cav2.1, Cav2.2, and Cav2.3 in patch-clamp assays (IC50s = >30 µM for all at -90 mV); reduces the viability of spheroid A549 lung cancer cells at 100 or 200 nM; decreases body weight gain and fat mass and increases lean muscle mass in mice fed a high-fat diet; inhibits amphetamine- or MK-801-induced locomotor activity in rats at 3 mg/kg; decreases the mean time spent in active wake and REM sleep and increases the mean time spent in delta sleep in wild-type but not Cacna1g-/- and Cacna1i-/- double knockout mice when administered one hour before the inactive phase at 10 mg/kg
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