Verosudil, CAS 1414854-42-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-a-(dimethylamino)-3-thiopheneacetamide

Purity: ≥98%

Formula Markup: C17H17N3O2S

Formula Weight: 327.4019

CAS Number: 1414854-42-4

Notes: A ROCK1 and ROCK2 inhibitor (Ki = 2 nM for both); selective for ROCK1 and ROCK2 over PKA, PKCθ, MRCKα, and CaMKIV (Kis = 69, 9,332, 28, and 5,855 nM, respectively); decreases focal adhesion points on, and actin fiber length in, primary PTM cells at 1 µM; inhibits TGF-β-induced increases in α-SMA levels in primary human conjunctival fibroblasts at 250 or 500 nM; inhibits TGF-β-induced migration in a wound healing assay using primary human conjunctival fibroblasts; reduces IOP in rabbits and Formosan rock monkeys when ocularly administered at 0.5%; decreases IOP and subconjunctival collagen levels in a rabbit model of trabeculectomy when ocularly administered at 0.5%

• Artikelnummer: CAY42234-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42234-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK