8-CPT-Cyclic AMP (sodium), CAS 93882-12-3

Product Description: 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50Epac and is a potent Epac activator[1][2].

Applications: COVID-19-immunoregulation

Formula: C16H14ClN5NaO6PS

References: [1]Connolly BJ, et al. 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem Pharmacol. 1992;44(12):2303-2306. /[2]Krakstad C, et al. cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). J Leukoc Biol. 2004;76(3):641-647.

CAS Number: 93882-12-3

Molecular Weight: 493.79

Compound Purity: 99.92

Research Area: Inflammation/Immunology

Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)

Target: Phosphodiesterase (PDE);PKA

• Artikelnummer: MEXHY-111673-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-111673-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK