Autotaxin-IN-7

Product Description: Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis[1].

Formula: C26H24N6O4

References: [1]Deyi Ma, et al. Development of Tricyclic 4,5-Dihydro-3 H-pyrrolo[2,3- c]quinolin-4-ones as Potent Autotaxin Inhibitors for Pulmonary Fibrosis Treatment In Vivo. J Med Chem. 2025 Apr 10;68(7):7476-7498.

Molecular Weight: 484.51

Research Area: Inflammation/Immunology

Target: Phosphodiesterase (PDE);TGF-β Receptor

• Artikelnummer: MEXHY-170227-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-170227-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK