AV457, CAS 2713387-11-0

Product Description: AV457 is a potent and selective mTOR inhibitor with an IC50 value of 0.54 µM. AV457 inhibits cyst growth in polycystic kidney disease (PKD) organoids. AV457 decreases the protein expression of P-s6, P-p70s6 and don’t decreases the protein expression of P-AKT[1].

Formula: C55H88N2O16S

References: [1]Gulieva RE, et al. A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease. Stem Cell Reports. 2025 Jan 9:102395.

CAS Number: 2713387-11-0

Molecular Weight: 1065.36

Research Area: Metabolic Disease

Target: mTOR

• Artikelnummer: MEXHY-168884-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-168884-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK