BMS-986449

Product Description: BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].

Applications: Cancer-programmed cell death

Formula: C21H21FN4O3

References: [1]Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85(8_Supplement_1): 2249-2249.

Molecular Weight: 396.41

Research Area: Cancer

Target: IKZF Family;Molecular Glues

• Artikelnummer: MEXHY-173630-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-173630-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK