Product Description: Buntanetap ((+)-Phenserine) is a selective acetylcholinesterase inhibitor. Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C20H23N3O2
References: [1]Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. J Prev Alzheimers Dis. 2023;10(1):25-33./[2]Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13(12):2109. /[3]Brossi A , Pei XF Greig NH (1996) Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties. Australian Journal of Chemistry 49, 171-181.
CAS Number: 116839-68-0
Molecular Weight: 337.42
Compound Purity: 99.71
Research Area: Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 230 mg/mL (ultrasonic)
Target: α-synuclein
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