Product Description: Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC50s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC50 of 10 nM[1].
Formula: C21H19FN6
References: [1]Maeyer JD, et al. Casein kinase 1 inhibitors for use in the treatment of diseases related to dux4 expression such as muscular dystrophy and cancer. WO2020249717
CAS Number: 1095706-65-2
Molecular Weight: 374.41
Research Area: Cancer
Target: Casein Kinase;p38 MAPK