CIB-L43, CAS 1082942-70-8

Product Description: CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration[1].

Formula: C15H16N2O3S

References: [1]Shi H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Phenylthiazole-5-Carboxylic Acid Derivatives Targeting Transactivation Response RNA-Binding Protein 2. J Med Chem. 2025 Jan 9;68(1):421-447.

CAS Number: 1082942-70-8

Molecular Weight: 304.36

Compound Purity: 99.71

Research Area: Cancer

Solubility: DMSO : 8.93 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Akt;PTEN;TGF-beta/Smad

• Artikelnummer: MEXHY-170791-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-170791-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK