Product Description: Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model[1].
Applications: Cancer-programmed cell death
Formula: C26H22Br3Cu3N8S4
References: [1]Gou Y, et al. Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer. J Med Chem. 2021 May 13;64(9):5485-5499.
CAS Number: 2480150-28-3
Molecular Weight: 1005.12
Research Area: Cancer
Target: Apoptosis;Fluorescent Dye
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