CRCD2, CAS 941185-83-7

Product Description: CRCD2 is a small molecule NT5C2 nucleotidase inhibitor with enhanced 6-mercaptopurine cytotoxic activity. CRCD2 can effectively reverse 6-mercaptopurine resistance caused by mutations in the NT5C2 gene or non-genetic activation mechanisms. CRCD2 combined with 6-mercaptopurine can enhance its cytotoxic activity in NT5C2 wild-type leukemia, showing its potential in the treatment of acute lymphoblastic leukemia[1].

Applications: Cancer-programmed cell death

Formula: C17H16N4O2S

References: [1]Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

CAS Number: 941185-83-7

Molecular Weight: 340.40

Compound Purity: 99.02

Research Area: Cancer

Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Endogenous Metabolite

• Artikelnummer: MEXHY-167710-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-167710-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK