Product Description: Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras[1].
Applications: COVID-19-immunoregulation
Formula: C19H34N2O
References: [1]Azizi SA, et al. Development of an Acrylamide-Based Inhibitor of Protein S-Acylation. ACS Chem Biol. 2021 Aug 20;16(8):1546-1556.
CAS Number: 2801702-34-9
Molecular Weight: 306.49
Compound Purity: 98.0
Research Area: Cancer; Inflammation/Immunology; Neurological Disease
Target: Acyltransferase
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