Product Description: Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C14H13N3
References: [1]Furet P, et al. Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. J Med Chem. 1993;36(10):1393-1400./[2]Minnaard-Huiban M, et al. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology. 2008;149(1):28-31.
CAS Number: 102676-87-9
Molecular Weight: 223.27
Compound Purity: 98.75
Research Area: Cardiovascular Disease
Solubility: DMSO : 110 mg/mL (ultrasonic)
Target: Cytochrome P450
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