DPP8/9-IN-1

Product Description: DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases[1].

Formula: C20H33N2O3PS

References: [1]Sewald L, et al. Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat Commun. 2025 Apr 3;16(1):3208.

Molecular Weight: 412.53

Research Area: Cancer; Inflammation/Immunology

Target: Dipeptidyl Peptidase

• Artikelnummer: MEXHY-176001-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-176001-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK