FM04, CAS 1807320-40-6

Product Description: FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].

Applications: Cancer-programmed cell death

Formula: C26H25NO4

References: [1]Liu Z, et al. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04. J Med Chem. 2023 Apr 25.

CAS Number: 1807320-40-6

Molecular Weight: 415.48

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: P-glycoprotein

• Artikelnummer: MEXHY-149277-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-149277-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK