Product Description: GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS)[1].
Applications: Neuroscience-Neurodegeneration
Formula: C19H20F4N6O2
References: [1]Jonathan S Katz, et al. A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66.
CAS Number: 1637394-01-4
Molecular Weight: 440.39
Compound Purity: 99.18
Research Area: Neurological Disease
Target: JNK