Product Description: HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors[1][2][3].
Applications: Cancer-Kinase/protease
Formula: C24H24F2N4O3.1/2C4H4O4
References: [1]Lines CL, et al. The integrated stress response in cancer progression: a force for plasticity and resistance. Front Oncol. 2023 Aug 3;13:1206561. /[2]Al-Rawi DH, et al. Targeting chromosomal instability in patients with cancer. Nat Rev Clin Oncol. 2024 Sep;21(9):645-659./[3]Al Azzani M, et al. Phytochemical-mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytother Res. 2024 Jul 3.
CAS Number: 3034479-99-4
Molecular Weight: 512.51
Compound Purity: 98.92
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: PERK
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