HLB-0532259, CAS 2566733-45-5

Product Description: HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-168440); Black: linker (HY-W007957); Blue: ligand for E3 ligase Cereblon (HY-41547))

Formula: C40H44N8O7

References: [1]Tang J, et al., Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 7:S2451-9456(24)00516-6.

CAS Number: 2566733-45-5

Molecular Weight: 748.83

Research Area: Cancer

Target: Aurora Kinase;PROTACs

• Artikelnummer: MEXHY-168439-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-168439-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK