Product Description: KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL)[1].
Applications: Cancer-Kinase/protease
Formula: C60H74ClN10O14PS
References: [1]Phillip CC Liu, et al. A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1865
CAS Number: 2502186-79-8
Molecular Weight: 1257.78
Compound Purity: 96.17
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Molecular Glues;STAT
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