Product Description: KT-362 free acid is an intracellular calcium antagonist with antiarrhythmic and vasodilatory effects. KT-362 free acid shows an antagonistic effect against norepinephrine (NE) induced vasoconstriction response, achieved by reducing inositol phospholipid hydrolysis, thereby reducing intracellular calcium mobilization. KT-362 free acid can be used to study the contraction and relaxation mechanisms of vascular smooth muscle, especially in exploring the role of intracellular calcium mobilization and inositol phospholipid hydrolysis in vascular contraction[1].
Applications: Neuroscience-Neuromodulation
Formula: C22H28N2O3S
References: [1]Kodama I, et al. Effects of KT-362, a new antiarrhythmic agent with vasodilating action on intracellular calcium mobilization of atrial muscle[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 258(1): 332-338.
CAS Number: 93392-97-3
Molecular Weight: 400.53
Research Area: Cardiovascular Disease
Target: Calcium Channel
Deutsch
English
