Product Description: Letaxaban (TAK-442) is an orally active and selective direct FXa inhibitor. Letaxaban is a drug with dual anticoagulant and anti-inflammatory activity that works by directly inhibiting FXa and by intervening in the PAR1 signaling pathway. Letaxaban can be used in the study of thrombotic diseases, cardiovascular diseases and inflammation-related diseases[1].
Applications: COVID-19-immunoregulation
Formula: C22H26ClN3O5S
References: [1]Shinozawa E, et al. TAK-442, a direct factor Xa inhibitor, inhibits monocyte chemoattractant protein 1 production in endothelial cells via involvement of protease-activated receptor 1[J]. Frontiers in Pharmacology, 2018, 9: 1431.
CAS Number: 870262-90-1
Molecular Weight: 479.98
Research Area: Inflammation/Immunology; Cardiovascular Disease
Target: Factor Xa