LXRα agonist 1, CAS 1790089-97-2

Product Description: LXRα agonist 1 (Compound 40) is a selective LXRα agonist (EC50: 42 nM). LXRα agonist 1 also has a certain agonistic effect on LXRβ (EC50: 266 nM). LXRα agonist 1 promotes target gene transcription by stabilizing the ligand binding domain (LBD) of LXRα. LXRα agonist 1 exhibits potent antitumor effects in hepatocellular carcinoma cells when combined with the Raf inhibitor Sorafenib (HY-10201). LXRα agonist 1 can be used in the study of lipotoxic cancers[1].

Applications: Cancer-programmed cell death

Formula: C28H27N3O2

References: [1]Galvez B Pedreira J, et al. Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies. J Med Chem. 2025 Apr 10;68(7):7180-7196.

CAS Number: 1790089-97-2

Molecular Weight: 437.53

Research Area: Cancer

Target: LXR

• Artikelnummer: MEXHY-173393-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-173393-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK