Product Description: MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 with good oral bioavailability. MKLP2-IN-1 inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro and suppresses tumor growth in a mouse Calu-6 lung cancer model[1].
Applications: Cancer-programmed cell death
Formula: C23H19BrFN3O2
References: [1]Huang J, et al. Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes[J]. European Journal of Medicinal Chemistry Reports, 2024, 11: 100145.
CAS Number: 2929345-46-8
Molecular Weight: 468.32
Research Area: cancer
Target: Kinesin