Nav1.2-IN-1

Product Description: Nav1.2-IN-1 (compound 5i), a 3-(1,2,3,6-tetrahydropyridine)-4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC50 value of 7.79 μM. Nav1.2-IN-1 exhibits antiepileptic activity. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ)-induced epilepsy mode[1].

Applications: Neuroscience-Neuromodulation

Formula: C20H18F3N3

References: [1]Bin Lou, et al. Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity. Eur J Med Chem. 2025 Aug 5:292:117664.

Molecular Weight: 357.37

Research Area: Neurological Disease

Target: Sodium Channel

• Artikelnummer: MEXHY-176065-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-176065-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK