NLRP3-IN-76

NLRP3-IN-76
Artikelnummer
MEXHY-170218-0
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MedChemExpress

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Product Description: NLRP3-IN-76 is an orally active NLRP3 inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα). NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS (HY-116282C)-induced colitis and can be used for research of inflammatory bowel diseases (IBD)[1].

Formula: C17H14N4O4

References: [1]Sun Z, et al. Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation. Bioorg Chem. 2025 Jun 1;159:108402.

Molecular Weight: 338.32

Research Area: Inflammation/Immunology

Target: Interleukin Related;NF-κB;NO Synthase;NOD-like Receptor (NLR)
Mehr Informationen
Artikelnummer MEXHY-170218-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-170218-0
Verpackungseinheit Get quote
Mengeneinheit STK
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