Product Description: Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM). Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research[1].
Formula: C24H18ClN5O2
References: [1]Gao YF, et al. Design, synthesis, and biological evaluation of quinolinyl-ureido-phenyl-hydrazide derivatives and quinolinyl-hydrazide derivatives as anticancer agents targeting Nur77-mediated ferroptosis. Eur J Med Chem. 2025 Jul 5;291:117559. 40215561.
CAS Number: 2899254-71-6
Molecular Weight: 443.89
Research Area: Cancer
Target: Ferroptosis;Glutathione Peroxidase;Nuclear Hormone Receptor 4A/NR4A;Reactive Oxygen Species
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