P162-0948, CAS 1358201-44-1

Product Description: P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].

Formula: C20H15FN4O2

References: [1]Lin TE, et al. Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening. J Chem Inf Model. 2025 Jan 13;65(1):378-389.

CAS Number: 1358201-44-1

Molecular Weight: 362.36

Research Area: Infection

Target: CDK;TGF-beta/Smad

• Artikelnummer: MEXHY-170813-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-170813-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK