P1D-34

Product Description: P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. P1D-34 also down-regulates Pin1 client proteins such as Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. P1D-34 shows anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines. P1D-34 induces cell DNA damage and apoptosis by releasing ROS generation. Pink: PIN1 ligand (HY-171442A), Blue: CRBN ligand (HY-14658), Black: Linker (HY-W014883)[1].

Applications: Cancer-Kinase/protease

Formula: C40H59ClN6O9S

References: [1]Shi Y, et al. Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia. Chem Sci. 2024 Feb 28;15(13):5027-5035.

Molecular Weight: 835.45

Research Area: Cancer

Target: Akt;Apoptosis;CDK;c-Myc;PIN1;PROTACs;Reactive Oxygen Species

• Artikelnummer: MEXHY-171334A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-171334A-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK