PARP1-IN-37, CAS 952474-39-4

Product Description: PARP1-IN-37 (Compound 8) is an orally active and selective poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor with an IC50 value of 24 nM for PARP1. PARP1-IN-37 inhibits PARP activity in cells with an EC50 value of 3.7 μM. PARP1-IN-37 is promising for research of BRCA-mutated tumors, such as breast and ovarian cancers[1].

Applications: Cancer-programmed cell death

Formula: C14H11N3O

References: [1]Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

CAS Number: 952474-39-4

Molecular Weight: 237.26

Research Area: Cancer

Target: PARP

• Artikelnummer: MEXHY-171543-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-171543-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK