Product Description: PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. PD-1/PD-L1-IN-55 promotes IFN-γ secretion and reduces the proportion of PD-L1 late apoptosis[1].
Formula: C25H23ClN2O3
References: [1]Lu T, et al. Design, Synthesis, Evaluation, and SAR of 5-Phenylisoindoline Derivatives, a Potent Class of Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 (PD-1/PD-L1) Interaction. J Med Chem. 2025 Apr 10;68(7):7291-7312.
CAS Number: 3052262-83-3
Molecular Weight: 434.91
Research Area: Cancer
Target: PD-1/PD-L1