PPZ2, CAS 896203-18-2

Product Description: PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects[1].

Applications: Neuroscience-Neuromodulation

Formula: C22H29N3O2

References: [1]Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

CAS Number: 896203-18-2

Molecular Weight: 367.48

Compound Purity: 99.92

Research Area: Neurological Disease

Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Calcium Channel

• Artikelnummer: MEXHY-111527-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-111527-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK