PROTAC HIF-1α degrader-1

Product Description: PROTAC HIF-1α degrader-1 (compound V2) is a potent hypoxia-inducible factor-1α (HIF-1α) PROTAC degrader with an IC50 value of 7.54 µM. PROTAC HIF-1α degrader-1 shows anti-proliferative activity. PROTAC HIF-1α degrader-1 decreases the HIF-1α protein expression. PROTAC HIF-1α degrader-1 induces apoptosis. (Pink: ligand for target protein (HY-111387); black: linker (HY-W013731); Blue: E3 ligase ligand (HY-112078))[1].

Applications: Cancer-programmed cell death

Formula: C51H72N6O7S

References: [1]Li Y, et al. Discovery of potent hypoxia-inducible factor-1α (HIF-1α) degraders by proteolysis targeting chimera (PROTAC). Bioorg Chem. 2024 Nov 4;153:107943.

Molecular Weight: 913.22

Compound Purity: 98.02

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Apoptosis;HIF/HIF Prolyl-Hydroxylase;PROTACs

• Artikelnummer: MEXHY-168641-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-168641-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK