PROTAC MAGL degrader-1

Product Description: PROTAC MAGL degrader-1 is an orally active PROTAC agent that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2. PROTAC MAGL degrader-1 degrades MAGL and inhibits the binding of MDM2 to p53. PROTAC MAGL degrader-1 can partially penetrate the blood-brain barrier (BBB). PROTAC MAGL degrader-1 induces glioblastoma stem cells (GSCs) apoptosis. (E3 ligase ligand: HY-128837; target protein ligand + linker: HY-173370; target protein inhibitor: HY-15249)[1].

Formula: C60H58Cl2N6O14

References: [1]Yuan Z, et al. MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell. Cell Death Discov. 2025 Mar 20;11(1):109.

Molecular Weight: 1158.04

Research Area: Cancer

Target: Ligands for E3 Ligase;MAGL

• Artikelnummer: MEXHY-173369-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-173369-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK