PROTAC PD-L1 degrader-1

Product Description: PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer. (Blue: CRBN ligand (HY-150839), Black: linker; Pink: PD-L inhibitor (HY-19745))[1].

Applications: Cancer-programmed cell death

Formula: C45H55N5O7

References: [1]Hongjia Zhang, et al. Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem. 2024 Jun 18.

Molecular Weight: 777.95

Research Area: Cancer; Inflammation/Immunology

Target: PD-1/PD-L1;PROTACs

• Artikelnummer: MEXHY-163757-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-163757-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK