S118, CAS 2677041-36-8

Product Description: S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P2 receptor) inhibitor. S118 prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P2 receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis[1].

Formula: C19H14Cl2FN7O

References: [1]Mu SY, et al. Inhibition of sphingosine-1-phosphate receptor-2 attenuates idiopathic pulmonary fibrosis by preventing its binding to dapper1 in bronchial epithelial cells. Br J Pharmacol. 2025 Apr 13.

CAS Number: 2677041-36-8

Molecular Weight: 446.27

Research Area: Inflammation/Immunology

Target: β-catenin

• Artikelnummer: MEXHY-176057-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-176057-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK