Product Description: Salirasib (Standard) is the analytical standard of Salirasib. This product is intended for research and analytical applications. Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.
Formula: C22H30O2S
References: [1]Makovski V, et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis.
Int J Cancer. 2012 Mar 15;130(6):1420-9./[2]Nevo Y, et al. Chapman J. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy.
PLoS One. 2011 Mar 22;6(3):e18049./[3]Charette N, et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition.
Mol Cancer. 2010 Sep 22;9:256.
CAS Number: 162520-00-5
Molecular Weight: 358.54
Research Area: Cancer
Target: Autophagy;Ras;Reference Standards
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