Product Description: Saquinavir mesylate (Standard) (Ro 31-8959/003 (Standard)) is the analytical standard of Saquinavir mesylate (HY-17003). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
Formula: C39H54N6O8S
References: [1]Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721./[2]Yerino GA, Halabe EK, Zini E, Feleder EC.
Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects.
Arzneimittelforschung. 2011;61(8):481-7./[3]Branham ML, Moyo T, Govender T.
Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.
Eur J Pharm Biopharm. 2012 Jan;80(1):194-202./[4]Brouwers J, Vermeire K, Grammen C, Schols D, Augustijns P.
Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.
Antiviral Res. 2011 Aug;91(2):217-23./[5]Knechten H, Lutz T, Pulik P, Martin T, Tappe A, Jaeger H.
Safety and Efficacy in HIV-1-Infected Patients Treated with Ritonavir-Boosted Saquinavir Mesylate.
CAS Number: 149845-06-7
Molecular Weight: 766.95
Research Area: Infection; Inflammation/Immunology; Cardiovascular Disease
Target: Apoptosis;Calcium Channel;HIV;HIV Protease;Interleukin Related;JNK;NO Synthase;p38 MAPK;Reactive Oxygen Species;Reference Standards;Toll-like Receptor (TLR)
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