Thalidomide 4'-ether-PEG2-azide, CAS 2758431-90-0

Product Description: Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1].

Applications: Cancer-programmed cell death

Formula: C19H21N5O7

References: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

CAS Number: 2758431-90-0

Molecular Weight: 431.40

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates

• Artikelnummer: MEXHY-157515-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-157515-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK