UNC8153, CAS 2929304-60-7

Product Description: UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].

Applications: Cancer-programmed cell death

Formula: C33H37N5O5

References: [1]Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188.

CAS Number: 2929304-60-7

Molecular Weight: 583.68

Research Area: Cancer

Target: Histone Methyltransferase

• Artikelnummer: MEXHY-157251A-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-157251A-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK