USP1-IN-11

Product Description: USP1-IN-11 (compound 38-P2) is a selective, reversible, and noncompetitive USP1 (Ubiquitin-specific protease 1) inhibitor. USP1-IN-11 activates the DDR (DNA damage repair) pathway, induces cell cycle arrest and cell Apoptosis, and inhibits cell survival. USP1-IN-11 enhances the sensitivity of Olaparib (HY-10162)-resistant cells to Olaparib (HY-10162) and shows a synergetic effect with Andrographolide (HY-N0191) in BRCA-proficient cancer cells. USP1-IN-11 displays significant, dose-dependent antitumor efficacy in the MDA-MB-436 xenograft model[1].

Formula: C31H30F3N7O3

References: [1]Zhang J, et al. Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors. J Med Chem. 2025 Feb 13;68(3):3673-3699.

Molecular Weight: 605.61

Research Area: Cancer

Target: Deubiquitinase

• Artikelnummer: MEXHY-170921-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-170921-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK